Few patients with Marfan syndrome live out a normal life span. However, data from patients at four referral centers suggest that the prognosis may. However, data from patients at four referral centers suggest that the prognosis may be improving for this autosomal dominant connective-tissue disorder, which is associated with aortic dissection and other cardiovascular abnormalities.
By comparison, a classic paper on the natural history of Marfan syndrome reported a mean age at death of 32 years. Compared with the analysis, the age at which half of patients are expected still to be alive has risen from 49 to 74 years for women and from 41 to 70 years for men.
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